Molecular Tests
- Plasmid DNA Molecular Size & Integrity Test
- Plasmid DNA Restriction Map Analysis
- Plasmid DNA Copy Number Quantification
Impurities
- Residual Plasmid DNA Template in Synthetic mRNA
- dsRNA Contamination Detection (ELISA)
- E.coli Host Cell DNA Analysis
- E.coli Host Cell RNA Analysis
RNA-related tests
- RNA Concentration Determination
- RNA Sequence Verification (qRT-PCR)
- mRNA Molecular Size & Integrity Test
- Small RNA Molecular Size & Integrity Test
- mRNA Primary Sequence Analysis (HPLC)
- mRNA Sequence Analysis (NGS)*
- Percentage of Poly-A Tailed mRNA
- Percentage of 5′-Capping Efficiency
- mRNA Encapsulation Efficiency (Fluorescence Assay)
- mRNA Encapsulation Efficiency (Gel Retardation Test)
DNA-related tests
- DNA Concentration Determination
- Plasmid DNA Identity Verification (Sanger Sequencing)
- Plasmid DNA Topology Analysis
- Plasmid DNA Linearization Efficiency Analysis
* These tests are not currently performed directly at ReNAP and are outsourced instead, and the final results are processed, interpreted and reported by ReNAP QC Department.
Biochemical Tests
- RNA Polymerase Promoter Specificity Test
- Re-ligation Assay (Restriction Enzyme Cutting Accuracy)
- Total Protein Concentration Determination (BCA)
- Protein Purity Analysis by SDS-PAGE
- E.coli Host Cell Protein Analysis
- RNase Inhibitor (RI) Activity Assay
- Phosphatase Activity Assay (pNPP)
- RNA polymerase Activity Assay
- Restriction Enzymes Activity Assay
- Exonuclease Activity Assay
- Endonuclease Activity Assay
- Non-Specific DNase Activity Assay
- RNase Activity Assay
- Latent RNase Activity Assay
- dNTPase Activity Assay
- NTPase Activity Assay
Cellular Tests
- Eukaryotic Cell Line Authentication
- Cell Viability Test
- Cytotoxicity Test (MTT Assay)
- Immuno-Cyto Chemistry Assay (ICC)
- Immuno-Histo Chemistry Assay (IHC)
- In Vitro Expression Assay (Western Blotting)
- In Vitro Expression Assay (Flow Cytometry)
Microbiological Tests
- E.coli Identification (16srRNA Genetic Analysis)
- Culture Purity test*
- Gram Staining test
- Bacterial Viability Test
- Plasmid Retention Test
- Microbial Limit Test*
- Bioburden Test*
- Bacterial Endotoxin Test (Gel Clot)
- Sterility Test*
- Presence of Bacteriophage
* These tests are not currently performed directly at ReNAP and are outsourced instead, and the final results are processed, interpreted and reported by ReNAP QC Department.
Physico-Chemical Tests
- Chemical Compound Identification (NMR spectroscopy)*
- Chemical Compound Identification (Mass spectroscopy)*
- Chemical Compound Identification (Raman spectroscopy)*
- Chemical Compound Identification (IR spectroscopy)*
- Physical Appearance
- Extractable Volume Measurement*
- Particulate Matter Test*
- Osmolality Test*
- pH Determination
Nano-Particles
- Nanoparticle Size & Polydispersity (PDI) Determination (DLS)
- Nanoparticle Zeta-potential Determination (DLS)
Chemical Compound Identification
- Heavy Metal Content (ICP-Mass)*
- Chemical Compound Identification (TLC)
* These tests are not currently performed directly at ReNAP and are outsourced instead, and the final results are processed, interpreted and reported by ReNAP QC Department.
Special Tests
- SARS-COV2 Pseudo type Virus Neutralization Tests (pVNT)
- Interferon β Quantification Assay
On-Demand QC Contract Service Packages
Certificate of Analysis Compilation
- Bacterial Cell Line
- Plasmid DNA (Supercoiled & Linearized)
- mRNA
- mRNA-LNP
- Specific Enzymes & Proteins
Comprehensive Stability Studies
Bioinformatic Analysis
- q-PCR Data Interpretation
- Next Generation Sequencing Analysis
